|
KMID : 1084220160230010047
|
|
Journal of Rheumatic Diseases
2016 Volume.23 No. 1 p.47 ~ p.54
|
|
|
Gastrointestinal Risk Factors and Non-steroidal Anti-inflammatory Drugs Use in Rheumatoid Arthritis and Osteoarthritis Patients in Korea
|
|
이은영:Lee Eun-Young
홍승재:Hong Seung-Jae/박용범:Park Yong-Beom/박경수:Park Kyung-Su/최찬범:Choi Chan-Bum/이창근:Lee Chang-Keun/송란:Song Ran/이윤종:Lee Yun-Jong/서창희:Suh Chang-Hee/김현아:Kim Hyun-Ah/민준기:Min Jun-Ki/윤종현:Yoon Chong-Hyeon/박원:Park Won/정원태:Chung Won-Tae/김근태:Kim Geun-Tae/최정윤:Choe Jung-Yoon/강성욱:Kang Seong-Wook/박용욱:Park Yong-Wook/류완희:Yoo Wan-Hee/이상헌:Lee Sang-Heon
|
|
|
Abstract
|
|
|
Objective : The aim of this study was to examine and compare the gastrointestinal (GI) risk factors and treatment patterns of rheumatoid arthritis (RA) and osteoarthritis (OA) patients in Korea.
Methods : This was a cross-sectional, observational study on RA and OA patients taking non-steroidal anti-inflammatory drugs (NSAIDs) for at least 1 month. A total of 1,896 patients (981 RA patients, 915 OA patients) were recruited from 20 university hospitals. Data were collected through medical records and patient surveys. GI risk factors included age, prolonged (over 3 months) or high-dose use of NSAIDs, alcohol drinking, smoking, use of aspirin, anticoagulants or glucocorticoids, comorbidities, and history of Helicobacter pylori infection or other GI complications. Treatment patterns were classified according to groups using, selective cyclooxygenase (COX)-2 inhibitors± gastro-protective agents, non-selective COX-2 inhibitors+proton pump inhibitor, or non-selective COX-2 inhibitors± other gastro-protective agents.
Results : GI risk factors were highly present in both RA and OA patients. The proportion of prolonged use of NSAIDs, smoking, and glucocorticoid use were higher in RA patients (p＜0.001). The proportion of comorbidities and use of aspirin were higher in OA patients (p＜0.001). The remaining GI risk factors were present in similar proportions in both groups. Use of selective COX-2 inhibitors or gastro-protective agents was higher in RA patients.
Conclusion : Prolonged use of NSAIDs and concomitant glucocorticoid use were higher in RA patients, while comorbidities and concomitant aspirin use were predominant in OA patients. These results will provide insights for use in development of future guidelines for proper selection of NSAIDs and effective prevention of GI complications in arthritis patients. (J Rheum Dis 2016;23:47-54)
|
|
|
KEYWORD
|
|
|
Rheumatoid arthritis, Osteoarthritis, Gastrointestinal risk factors, Non-steroidal anti-inflammatory agents
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|